ZenToks Publication

Chapter 2

Role of Herbal Polymers in Enhancing Permeability

Abstract/Preface

The skin is a strong protective barrier that challenges drug delivery. Among the key parameters determining drug permeation, the role of polymers is also becoming increasingly important in skin permeation. Polymers increase the permeability of the skin by interacting with the stratum corneum, the outermost skin layer, and adjusting the structure to allow easier drug diffusion. Herbal polymers, such as chitosan and alginate, along with cellulose derivatives, receive special attention due to their natural origin, being biodegradable, and biocompatible. These polymers ensure improvement in drug solubility, sustained release system establishment, and reduction in the degradation of drugs. An example is chitosan, which interacts with lipids in the skin by enhancing permeability and having a gel-like matrix developed by alginate that establishes steady drug release. Other hydroxypropyl methyl celluloses are cellulose derivatives that work like viscosity modifiers and could raise skin retention in formulations. Additional factors like polymer compatibility with the active drug govern size in terms of molecular charge which determines effectiveness in penetration with the skin. These help overcome inherent resistance in a controlled, targeted delivery with minimal systemic side effects by the skin. Thus, such polymer-based formulations could now promise advanced transdermal therapy solutions with better therapeutic efficacy and patient compliance.